Academic expertise for research projects, on demand
We give companies and research groups access to specialized academic expertise without the overhead of building it in-house. Each project combines the scientific oversight of experienced principal investigators with the hands-on work of active researchers, with Tengene as your single contracting partner.
How we work
Our initial focus is RNA biology, custom assay development, custom sequencing experiments, bioinformatics and biostatistics, and we are continuously expanding our expertise.
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One contracting partner
We handle contracts, confidentiality, data security and project management, so projects can start quickly and scale as needed.
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Senior oversight, hands-on researchers
Experienced principal investigators guide each project scientifically; active researchers do the work.
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Your data stay in Switzerland
Your data are processed exclusively on dedicated, secure high-performance computing infrastructure in Switzerland, and the results we generate for you belong to you.
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Wet lab when you need it
We also offer wet-lab work for assay development and other experiments on a project basis, in agreed bench space at a shared laboratory facility in Basel that we activate as soon as a project is confirmed.
Our current expertise
RNA sequencing and assay design
- Workflow consulting
- RNA extraction, custom library preparation and troubleshooting.
- Sequencing platforms
- Optimization of library preparation for Element Biosciences AVITI, Oxford Nanopore and Illumina.
- Translatome profiling
- Ribo-seq and polysome profiling.
- Specialized analyses
- Alternative polyadenylation, poly(A) tail length, translation dynamics and identification of novel open reading frames.
- Lab consulting
- Remote or on-site advice on implementing and troubleshooting workflows in your laboratory.
Experimental design for perturbation studies
- RNA-targeted CRISPR and siRNA experiments
- Target selection, controls, replication and readouts matched to your biological question.
Bioinformatics and biostatistics
- End-to-end analysis
- From raw reads to biological interpretation for all of the above, including integration with other omics data.
- Tailored methods
- Computational pipelines and statistical approaches for cases where off-the-shelf tools fall short.
- Nanopore data analysis
- Optimized basecalling, read alignment and in-depth quality control.
Machine learning for transcriptomic data
- Models built for your question
- Machine-learning and deep-learning models for interpreting transcriptomic and other complex biological data, built for your dataset and question rather than adapted from a generic tool.
Secure data infrastructure
- Infrastructure consulting
- Secure computing environments, scalable cloud deployment and data-protection-compliant integration of AI tools for sensitive biological data.
Founded by researchers
Tengene GmbH is a start-up founded by three researchers at the Biozentrum of the University of Basel.
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Dr. Aleksei MironovCo-founder -
Dr. Nitish MittalCo-founder -
Prof. Dr. Mihaela ZavolanCo-founder
Tell us about your project
Send us a short description of your data and your question. We’ll reply with how we would approach it and what it would involve.
Email info@tengene.ch